AbstractA German university is working on bone-replacement by non-embryonic dental stem cells that can be stimulated to become bone forming cells or tissue. The osteogenic potential of these cells is higher than that of other cells. High quality replacements for patients with periodontal diseases are to be offered. Partners from medical industry are sought for co-development and commercial use (under license).
DetailsPeriodontal disease, edentulism (tooth loss), cysts and malignant tumors are some of the major causes of bone loss in the periodontium. For patients suffering from these diseases a long lasting high quality replacement is essential.
Dental stem cells become increasingly attractive for the use in bone regeneration.
In the present invention of a German university, nonembryonic stem cells from apical perifollicular tissue (dental neural crest-derived progenitor cells, dNC-PCs) of retained human third molars have been isolated and characterized as osteogenic progenitor cells.
The cells have been derived from a tissue that is located in the immediate vicinity of immature developing teeth or wisdom teeth. The living soft tissue residing underneath the dental papilla is clearly distinguished from other tooth tissue, such as dental papilla or follicle. The neural crestderived and multipotent cells can be stimulated to differentiate into bone-forming cells or craniofacial cells or tissue as well as into nerve tissue. Because the dNC-PCs are neural crest derived and express the corresponding markers, they should be suitable to replace all the neural crest-derived craniofacial tissues.
Possible fields of application include bone replacement and healing and regeneration of dental pulp tissue.
• Variable application of non-embryonic stem cells that can be stimulated to differentiate into bone forming cells or craniofacial cell or tissue as well as into nerve tissue
• Higher osteogenic potential than other cells
• Autologous and/or allogeneic applications are conceivable