Title of Profil	Innovative chitosan-based biomimetic scaffold for wound repair and tissue engineering
Reference	12 BE 0324 3OHZ
Country of origin	Belgium
Offers/Requests	Offer
Entry/Update	2012-06-29 / 2013-05-22
Status	update

Abstract

A research team of a Belgian University has developed a tridimensional-layered chitosan scaffold. This scaffold offers potential applications in wound repair, tissue engineering.The research team is looking for collaboration with companies for joint development, testing and in vivo evaluation.

Details

The primary function of a wound dressing is the protection against environment. For extended wounds or hard-to-heal ulcers, additionnals properties would be highly desirable, such as the stimulation of the healing process or the improvement of the overall quality of the repaired tissue.This research team of scientists have developed a tridimensional-layered chitosan scaffold made of : o a porous support (sponge) allowing absorbance of exudates;o a nanofiber membrane allowing adhesion and proliferation of endothelial cells, keratinocytes and fibroblasts. The nanofiber membrane is electrospun onto the porous support layer. The whole device is stabilized by the fusion of the 2 layers. For illustration, see picture.Innovative Aspects:- Fully biocompatible - Allows adhesion, growth and differentiation of the main cell types of the skin - Progressive integration and remodeling of the nanofibrillar compartment in vivo - Stimulation of the closure of skin wounds in vivo - Easy manipulation of the whole device - Possibility to peel off the support (sponge) layer, keeping the wound bed intact during the renewal of the dressing and allowing use of chitosan nanofibrillar scaffold as a guide to facilitate tissue repair.

Technology sector	- Medicine, Human Health - Medical Technology / Biomedical Engineering - Single Use Products and Consumer Goods
Market application	- Therapeutic - Other Medical/Health Related - Disposable products
Stage of development	Available for demonstration
Patent Rights (IPR)	Patent(s) applied for but not yet granted
	WO 2011/151225A1
Cooperation type	- License Agreement - Joint further development - Testing of new applications - Adaptation to specific needs Type of partner sought: companies involved in wound dressing developmentSpecific area of activity of the partner: wound dressingTask to be performed by the partner sought: in vivo testing and further development
Organisation type	Research institute/University      Org. Size: 11-50

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